Preventive effect of MK-733 on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in JW rabbits.
نویسندگان
چکیده
منابع مشابه
Effect of simvastatin (MK-733) on sterol and bile acid excretion in rabbits.
The effects of Simvastatin (MK-733), an inhibitor of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, on fecal and biliary excretion of sterols and bile acids were examined using rabbits. Multiple doses of MK-733 (10 mg/kg/day) for 7 days were found to increase fecal concentrations of neutral sterols in cholesterol-fed rabbits, but not to affect those of bile acids. Multiple doses of cholest...
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15 صفحه اولIncreased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.
OBJECTIVE Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis. APPROACH AND RESULTS We generated transgenic (Tg) rabbits expres...
متن کاملEffect of Dihydrocholesterol and ^-Sitosterol on Cholesterol Atherosclerosis in Rabbits
While dihydrocholesterol lowered total plasma cholesterol in the rabbit, it did not promote the regression of either the aorta lipid fractions or plaque areas in atherosclerotic animals. A comparative study of the toxicities of /3-sitosterol and dihydrocholesterol disclosed that dihydrocholesterol, fed for a 7 month period, resulted in aorta plaque formation and caused the development of liver ...
متن کاملSpirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet.
The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. The animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% cholesterol for 4 wk, and then fed a HCD supplemented with 1 or 5% spirulina (SP1 or SP5) for an additional 8 wk. Spirulina supplementation lowered intimal surface of ...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1988
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.19.397